Rob Page is gearing up to lead his country to their first World Cup since 1958 and, naturally, all of the focus will be on Qatar.
Still, the fact Wales sit bottom of their group will be a concern. While Welsh football has largely been one big success story in recent years, relegation from Group A4 would be hugely disappointing.
For Belgium, this World Cup seems like one too far for their much-heralded golden generation in terms of genuine expectations to win it. They do, however, still boast a huge amount of quality.
Here’s everything you need to know about the game.
Date, kick-off time and venue
The Nations League game is scheduled for a 7.45pm kick-off time on Thursday September 22, 2022.
The King Baudouin Stadium in Brussels will host.
Where to watch Belgium vs Wales
TV channel: The game will be broadcast on S4C and Premier Sports 1.
Live stream: The S4C Player (free with a subscription) will offer a live stream.
Belgium vs Wales team news
Both Ben Davies and Joe Allen are missing from the Wales squad, although Page is not concerned about either injury problem being a long-term one.
Harry Wilson, Gareth Bale and Aaron Ramsey are also likely to miss out, although all will play major roles at the World Cup.
For Belgium, Romelu Lukaku is missing through injury.
Belgium vs Wales prediction
Given the number of key players missing for Wales, a home win looks likely.
Belgium to win 2-1.
Head to head (h2h) history and results
Belgium wins: 6
Wales wins: 5