The planned new strike dates are set to affect millions of people travelling for Christmas and cause severe disruption for Chelsea supporters travelling to their game against Bournemouth at Stamford Bridge on December 27.
Leyton Orient fans will also be impacted by the rail strikes as the League Two leaders host Stevenage on December 27.
There are no train services on Boxing Day, when Brentford host Tottenham, Crystal Palace play Fulham and Arsenal are at home to West Ham.
Millwall, QPR and Watford are all in action in the Championship on Boxing Day, Charlton play in League, while AFC Wimbledon and Sutton United have games in League Two.
As well as the planned strikes on December 24-27, industrial action at 14 train companies across four 48-hour periods will take place on: December 13-14, December 16-17, January 3-4 and January 6-7.