MitoBurn (L-B-Aminoisobutyric Acid) – 500 mg
MitoBurn, also known as L-β-Aminoisobutyric Acid (L-BAIBA), is a trademarked ingredient from NNB Nutrition.
The L-BAIBA molecule is in the myokine class. Myokines are non-protein amino acids that muscles synthesize in response to intense physical activity. They also have hormone-like effects in the body.
The basic function of myokines is to help regulate growth (anabolism) and muscle tissue breakdown (catabolism) in response to changing conditions. But L-BAIBA is special, and has some additional effects that we consider pretty phenomenal.
How L-BAIBA is produced, and what it does
When you begin exercising, your body converts the essential amino acid valine into L-BAIBA. Veteran supplement consumers probably recognize valine as one of the three branched-chain amino acids (BCAA), which are famed for their outsize anabolic effects.
Your muscles then release L-BAIBA into the bloodstream, where it circulates throughout your body.
The presence of L-BAIBA in your blood is a signal that exercise is underway – not just to muscle cells, but to many other types of cells as well. In response to L-BAIBA, the body undergoes numerous metabolic changes that help it cope with and recover from exercise.
For example, the body’s rate of fat burning goes up, which makes more energy available to your cells for use during activity. It also begins producing factors that help protect bone tissue from loading stress, thus decreasing the risk of bone injury.
Exercise in a pill?
So if L-BAIBA is the molecule responsible for triggering your body’s adaptations to exercise, then it seems obvious to ask: Is L-BAIBA essentially exercise in a pill?
There are some benefits of exercise that L-BAIBA won’t capture. But based on current research, it seems pretty clear that L-BAIBA is the closest thing to exercise in a pill that we’ve found.
The research shows that L-BAIBA can:
- Increase the rate at which the body burns fat[1,2,4-6]
- Increase the production of ketones from fatty acids
- Increase insulin sensitivity and decrease blood glucose levels[1,2,8]
- Decrease systemic inflammation
- Improve blood cholesterol and triglycerides[1,2]
- Increase bone density
- Support healthy kidney function
Obviously this is a very impressive list. Not all the benefits of exercise are listed here, but there are a lot of them. The thing we’re most interested in right now, though, is L-BAIBA’s ability to help burn fat.
So how does that work?
L-BAIBA’s fat burning mechanism: converting WAT to BAT
There’s one more crucial thing that L-BAIBA can do: convert white adipose tissue (WAT) into brown adipose tissue (BAT).[5,6]
The conversion of WAT to BAT is the primary mechanism behind L-BAIBA’s fat-burning properties, and it’s a powerful one. If you dig deep enough into the research on all the top-tier fat-burning ingredients, you’ll find that most drive the conversion of WAT to BAT.
The reason this works for fat loss is that having more BAT increases the number of calories your body burns in a day.
How BAT burns calories: non-shivering thermogenesis (NST)
To understand how this process works, we need to look at the essential difference between WAT and BAT.
Your body uses WAT as long-term energy storage – this is where it keeps emergency calories that can help you survive a famine.
BAT, on the other hand, is not just storage. It’s metabolically active tissue.
The name brown adipose tissue comes from the difference in appearance between WAT and BAT. WAT is more or less pure body fat and, as such, it’s basically transparent: it looks white when illuminated under a microscope. BAT looks dark brown when illuminated, because it’s so jam-packed with mitochondria that light is actually occluded
When your body converts WAT to BAT – say, by taking MitoBurn – what’s actually happening is new mitochondria are growing inside your WAT. MitoBurn drives this conversion by activating peroxisome proliferator-activated receptor-gamma coactivator (PGC-1) alpha and peroxisome proliferator-activated receptor (PPAR) alpha.[5,13]
Regular readers of the PricePlow Blog may perk up at this since we constantly harp on mitochondrial biogenesis, usually through PGC-1 alpha and PPAR alpha. They’re the key to health and longevity.
Well, in this case, it’s helping you burn fat faster.
That’s because the mitochondria inside BAT are busy: they continuously burn calories as heat in a process called non-shivering thermogenesis (NST).[5,11] The purpose behind NST is to help the body maintain its core temperature in the face of cold exposure, which is why cold exposure itself also can increase your body’s ratio of BAT to WAT.
The more BAT you have, the higher your total daily energy expenditure (TDEE), the number of calories your body can burn in a day. So, increasing NST by converting WAT to BAT can accelerate your rate of weight loss.[14,15]
Other benefits of BAT: improved cardiometabolic health
Because the mitochondria in BAT work by burning glucose and fatty acids in the bloodstream, increasing your body’s proportion of BAT can also improve blood glucose, cholesterol, and triglyceride levels.
The biochemical mechanism of NST: mitochondrial uncoupling
This section is for those of you who really want to dig into the nitty-gritty of why WAT to BAT conversion is such a powerful fat loss mechanism.
The mitochondria inside BAT are characterized by their expression of a protein called uncoupling protein 1 (UCP1). It basically short-circuits the electron transport chain (ETC) that mitochondria use to generate energy.
In crude terms, if you think of the ETC as an electrical circuit, UCP1 works by short-circuiting it. If you short-circuit an electrical circuit, it will arc, radiating intense light and heat. That’s basically what happens when UCP1 short-circuits the ETC.
The significance of this is in the name uncoupling protein – by short-circuiting the mitochondria inside BAT, UCP1 also de-couples the metabolic activity of mitochondria from your body’s overall metabolic demands.
This translates to a big increase in calorie burn that’s independent of variables like your level of physical activity.
And again, when UCP1 causes mitochondria to burn more fuel in the form of glucose and fatty acids, it can actually increase insulin sensitivity, glycemic control, and blood lipids, exerting an anti-obesity effect.
The reason we write L-BAIBA and not simply BAIBA is that the L-isomer is the only form of BAIBA that actually works in humans.[1,4] The other two – D-BAIBA and R-BAIBA – are not useful.
NNB’s MitoBurn is a carefully standardized form of BAIBA that consists of only L-BAIBA, making it exceptionally effective compared to more generic BAIBA supplements.
This is a bit more detailed than what we wrote in the MetaBurn AM and MetaBurn PM articles, but if you want to learn even more about MitoBurn (yes, there’s actually more), you should check out our long-form article titled BAIBA: Weight Loss Ingredient Generates Exercise in a Pill?!
InnoSlim (Panax Notoginseng Root & Astragalus Membranaceus Root Powder) – 500 mg
InnoSlim is a combination of ginseng and astragalus extracts developed by NuLiv Science.
NuLiv offers a range of extracts from these two plants. They contain so many different bioactive constituents that you can get very varying effects depending on what you standardize the extract for. Many customers have heard of their other ingredient, AstraGin, which boosts absorption. In the case of InnoSlim, we have a blend of extracts that are intended to maximize fat burning, insulin sensitivity, and cardiometabolic health.
In order to maintain healthy body composition and insulin signaling, we need adiponectin, a hormone that controls fat burning and gluconeogenesis (your liver’s mechanism for converting protein to glucose).
According to research on adiponectin, it:
- Inversely correlates with visceral fat
- Inversely correlates with blood glucose levels
- Inversely correlates with risk of diabetes
So, in other words, the more adiponectin your body produces, the less visceral fat you’ll have, the lower your blood sugar will be, and the lower your risk of diabetes is.
Fortunately for us, certain bioactive constituents of InnoSlim have been shown to significantly increase the body’s production of adiponectin.
AMP-activated protein kinase (AMPK)
Your body uses an enzyme called AMP-activated protein kinase (AMPK) to maintain its cellular energy balance. When your cells’ ATP stores get too low, AMPK is their signal to produce more of it.
Unsurprisingly, AMPK upregulation has been shown to increase the body’s rate of burning fat and glucose. Increased AMPK activity is associated with better insulin sensitivity and less visceral fat.
Again, key constituent molecules of InnoSlim can upregulate AMPK.
Glucose Transporter 4 (GLUT4)
When your cells need glucose to burn, something has to move that glucose out of your bloodstream and into the cells where it’s needed. Performing that transfer is the function of glucose transporter 4 (GLUT4).
There are a number of glucose transporter proteins in the body, each with a different area of responsibility. GLUT4 is primarily responsible for shuttling glucose into muscle and fat tissue.
Upregulating GLUT4 basically increases insulin sensitivity, meaning that more glucose moves into your cells in response to insulin signaling. This makes it a viable strategy for improving glycemic control and keeping blood sugar from rising too high.
Once again, some of the biologically active molecules in InnoSlim have been shown to upregulate GLUT4 in both muscle and fat tissue.[26,27]
Sodium Glucose Transporter 1 (SGLT1)
Another glucose transporter is sodium glucose transporter 1 (SGLT1). It performs the same essential function as GLUT4, except it occurs primarily in the digestive tract – SGLT1 is what helps your intestines absorb dietary carbohydrates from the food you eat.
Certain compounds in InnoSlim have been shown to inhibit the operation of SGLT1 by an impressive 25%. It can have an anti-obesity effect by decreasing the number of calories you’re taking in.
The phosphorylation of the acetyl coenzyme A carboxylase (ACC) can inhibit lipogenesis, your body’s process of storing excess energy as body fat.[30,31] This process is abbreviated as ACC-P.
Fortunately for us, some of the ginsenosides in InnoSlim have been shown to increase ACC-P in vitro.
We dive deeper into this ingredient in another article titled InnoSlim: Potent Stim-Free Weight Loss Ingredient by NuLiv Science.