A superb 29-23 victory at Twickenham in round one got Gregor Townsend’s side off to the perfect start and they once again hold rugby’s Calcutta Cup, but they must now defy recent history.
In both 2021 and 2022, Scotland beat England in their first Six Nations match before losing to Wales a week later, bringing an immediate halt to the momentum that had been generated.
Townsend’s men will believe this is a Wales side that are there for the taking though, after they were beaten 34-10 by ruthless Ireland in Cardiff. Even Warren Gatland appears unable to turn their fortunes around in the short timeframe he’s been given.
Victory here for the Welsh would get things back on track, while Scotland will be desperate to arrive in Paris in a fortnight’s time right in the thick of the battle at the top of the standings.
Scotland vs Wales date, kick-off time and venue
Scotland vs Wales is the second Six Nations match on Saturday, February 11, after Ireland face France in a blockbuster clash in Dublin earlier in the day.
The game is due to begin at 4:45pm GMT, taking place at Murrayfield in Edinburgh.
How to watch Scotland vs Wales
TV channel: Scotland vs Wales is being broadcast live and free-to-air on BBC One, with coverage beginning at 4pm. Live coverage is also available on Welsh-language channel S4C from 4pm.
Live stream: Fans can also follow all the action as it happens live online via the BBC Sport website, BBC iPlayer or S4C Clic.
Scotland vs Wales team news
Scotland have made one change to the XV who started against England, with Zander Fagerson returning from a hamstring injury and back at tighthead prop in place of WP Nel, who drops to the bench.
Fagerson’s return means that Glasgow Warriors team-mate Simon Berghan drops out of the matchday squad altogether.
There is still no Hamish Watson after concussion problems as Luke Crosbie continues alongside captain Jamie Ritchie and Matt Fagerson in the back row.
There’s a changing of the guard of sorts for Wales after that chastening defeat by Ireland, with former captain Alun Wyn Jones and Justin Tipuric cut from the squad completely and Taulupe Faletau demoted to the bench.
In come young duo Dafydd Jenkins and Christ Tshiunza, making their first Wales and Six Nations starts respectively, alongside Tommy Reffell, with Jac Morgan moving to number eight in a far more youthful pack.
Wyn Jones is back at loosehead after missing the autumn through injury, with Dillon Lewis in on the other side of skipper Ken Owens as Gareth Thomas and Tomas Francis drop out.
Gatland has kept his backline the same, with Joe Hawkins and Rio Dyer again lining up along with Josh Adams, Liam Williams, George North and half-back pairing Tomos Williams and Dan Biggar.
Scotland vs Wales lineups
Scotland XV: Hogg, Steyn, Jones, Tuipulotu, Van der Merwe; Russell, White; Schoeman, Turner, Fagerson; R Gray, Gilchrist; Ritchie (c), Crosbie, M Fagerson.
Replacements: Brown, Bhatti, Nel, J Gray, Dempsey, Horne, Kinghorn, Harris.
Wales XV: L Williams; Adams, North, Hawkins, Dyer; Biggar, T Williams; W Jones, Owens (c), Lewis, Jenkins, Beard, Tshiunza, Reffell, Morgan.
Replacements: Baldwin, Carre, Brown, Davies, Faletau, Webb, Patchell, Cuthbert.
Scotland vs Wales head to head (h2h) history and results
Wales have enjoyed plenty of success over Scotland, winning 18 of the past 21 matches between the two sides.
Scotland wins: 50
Wales wins: 75
Scotland vs Wales prediction
A statement victory followed by a stumbling performance has been a regular theme for Scotland, and their task is to ensure a hat-trick of wins over England is not followed by a hat-trick of defeats to Wales.
They can take plenty of confidence from their ruthless Twickenham display, while Townsend has insisted his side “can grow more” in the weeks ahead.
History is not necessarily on their side – Scotland have never won their first two matches of the Six Nations and they have never beaten Warren Gatland.
What is on their side is a Wales team that struggled badly in Cardiff last week, even if Ireland, the best team in the world, will prove far too good for most sides.
Gatland went for experience in the opening game, but a number of those trusted players looked to be past their best and changes had to be made. This would arguably be the most disappointing of all the recent defeats Scotland have suffered to Wales, but they should be confident of coming out on top.
Scotland to win, by 10 points.
Scotland vs Wales odds
Scotland to win: 4/11
Wales to win: 12/5
Odds via Betfair (subject to change).